Arsenal will face Bayern Munich, Leicester City will play Sevilla and Manchester City are up against Monaco in the Champions League last 16.
The Gunners have played the German champions four times in the previous five campaigns and finished behind them in the group stage last season.
The Foxes, in their debut campaign, have a tough test against Europa League champions Sevilla.
Manchester City’s opponents Monaco beat Tottenham twice in Group E.
One of the other standout ties of the round puts Spanish champions Barcelona against French champions Paris St-Germain. Barca beat PSG in the quarter-finals en route to winning the title during the 2014-15 season.
Champions and La Liga leaders Real Madrid face Italian side Napoli, who are fourth in Serie A.
The Premier League’s three representatives in the last 16 of the Champions League have all been handed tough draws – but also ties that will offer them the realistic opportunity of progress.
Arsenal, reigning champions Leicester City and Manchester City could have been given easier opponents but there will also be guarded optimism surrounding the prospect of facing Bayern Munich, Sevilla and Monaco.
The Gunners are aiming to end a run of six successive exits at this stage and some may curse the draw that pairs them with Bayern.
It is not a comfortable reward for topping their group and they have suffered before against Bayern in this competition.
Leicester City will give anyone a tough time if they play with the intensity and power they showed in thrashing Manchester City.
Monaco’s displays in beating Tottenham home and away will have warned Manchester City manager Pep Guardiola about their quality, and he also has serious defensive issues to address.
Real Madrid will take on Serie A side Napoli, as they look to defend the crown they claimed under Zinedine Zidane last season.
Barcelona face a tough test against Paris Saint-Germain in the last 16 – who they faced in the group stage last term and the quarter-finals back in 2014-15 and 2012-13 – while Leicester City’s continental adventure will continue against Sevilla, with the reigning Premier League champions having impressed so far.
The other ties at the first knockout stage will see Benfica tackle Borussia Dortmund, Porto lock horns with Juventus and Bayer Leverkusen attempt to halt the charge of 2015-16 beaten finalists Atletico Madrid.
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