Manager Nuno Espirito Santo will leave Wolves at the end of the season by mutual agreement.
The 47-year-old Portuguese, who left Porto to take charge in 2017, won the Championship title in his first season.
Wolves finished seventh in the Premier League in the past two seasons, and in September Nuno signed a three-year contract extension to 2023. “We achieved our goals, we did it with passion and we did it together,” he said.
Wolves are 12th heading into the final game of the season at home to Manchester United on Sunday.
“Since the first day we arrived at Compton [training ground], our ambition was to make a positive change and push this football club forward,” said Nuno.
“I am proud to say that we did that every single day.
“Sunday will be a very emotional day but I am so happy that the fans will be back in Molineux and we can share one last special moment together, as one pack.”
Under Nuno, Wolves collected 99 points on their way to the Championship title in 2017-18, finishing nine points clear of second-placed Cardiff with 30 wins from 46 games.
They continued to impress in the top flight with their slick, attacking football.
Wolves went on to win their Europa League qualifiers to secure a place in the group stage – and a return to European football for the first time in 39 years.
Despite starting their season earlier that most sides and playing 59 games in all competitions, they again finished seventh in the Premier League while reaching the Europa League quarter-finals.
Under Nuno and aided by the influence of agent Jorge Mendes, Wolves signed several Portuguese players, including Joao Moutinho, Diogo Jota, Ruben Neves and Fabio Silva.
“Nuno has brought us some incredibly special moments at Wolves that will never be forgotten but every chapter comes to an end,” said Wolves chairman Jeff Shi.
“His loyalty and dedication over the last four years has been immeasurable and we cannot thank him enough for the progress he has made for Wolves.
“Sunday was already going to be a very special day, welcoming our supporters back for the first time in more than a year, but it will also now be a fitting goodbye for someone who will forever remain an important part of Wolves history.”